Dab tsi yog qhov txawv ntawm PVC thiab PVDC
PVC
Cov khoom siv yooj yim tshaj plaws rau cov ntawv xaib yog polyvinyl chloride (PVC). Cov txiaj ntsig tseem ceeb ntawm PVC yog tus nqi qis thiab yooj yim ntawm thermoforming. Lub ntsiab cov ntsiab lus tsis zoo yog qhov tsis zoo tiv thaiv kev ya raws thiab cov pa oxygen. Nyob rau hauv cov ntaub ntawv ntawm blister ntim lub PVC daim ntawv tsis muaj ib tug plasticizer thiab qee zaum kuj hu ua Rigid PVC lossis RPVC. Thaum tsis muaj cov tshuaj pleev ib ce, PVC cov hlwv tawm muaj cov txheej txheem kom nruj thiab lub cev tiv thaiv rau cov kws tshuaj daim ntawv tshuaj. Ntawm qhov tod tes, hlwv hniav kab noj hniav yuav tsum nyob twj ywm siv tau los ntawm cov laub-sib zog thiab lub vev xaib tsim los yuav tsis nyuaj dhau los sib tsoo thaum nias thaum; vim li no PVC ntawv tuab feem ntau xaiv ntawm 200μ txog 300μ nyob ntawm kab noj hniav loj thiab me. Cov ntawv PVC feem ntau rau kev lag luam blisters yog 250μ lossis 0.250 hli hauv thickness. Cov nqi sib txawv rau Cov Dej Vapor Kis Tus Nqi (WVTR lossis MVTR) ntawm 250μ PVC zaj duab xis yog ib puag ncig 3.0 g / m2 / hnub ntsuas ntawm 38 ° C / 90% RH thiab Oxygen Transmission Rate (OTR) yog ib puag ncig 20 mL / m2 / hnub. Txhawm rau kov yeej qhov tsis muaj teeb meem ntawm PVC zaj duab xis, nws tuaj yeem raug nrog PVDC lossis laminated rau PCTFE lossis COC kom muaj zog ntxiv cov khoom tiv thaiv. Ntau txheej blister cov yeeb yaj kiab raws li PVC feem ntau siv rau kev lag luam tshuaj blister ntim, uas yog cov PVC ua haujlwm ua qhov thermoformable caj qaum ntawm tus qauv. Tsis tas li, PVC txheej tuaj yeem ua xim nrog cov xim thiab / lossis cov ntxaij lim dej UV. European Pharmacopoeia (Ph Eur) ua pov thawj txog cov xav tau rau PVC blister pob rau cov kws kho mob qib ntim hauv monograph EP 3.1.11 "COV NTAUB NTAWV TAU RAU NON-PLASTICISED POLY (VINYL CHLORIDE) RAU TXHEEJ TXHEEM RAU ZAUB MOV DOSAGE FORMS FOR ORAL ADMINISTRATION". Txhawm rau kom tsim nyog rau cov tshuaj ntim cov tshuaj pob txha, cov qauv PVC tseem yuav tsum ua raws li Asmeskas Pharmacopoeia< 661>="" ;;="" eu="" txoj="" cai="" khoom="" noj="" khoom="" haus;="" us="" 21.cfr="" thiab="" nyij="" pooj="" cov="" lus="" sib="" cuag="" khoom="">
PVDC
Polyvinylidene chloride (PVDC) tuaj yeem pleev xim rau PVC zaj duab xis kom tau txais cov cua kub siab heev thiab cov pa oxygen raws li qhov hnyav txheej. PVDC coated blister film yog cov feem ntau thiab muaj qhov thaiv teeb meem cov yeeb yaj kiab siv rau kev muab tshuaj blister ntim. Cov txheej txheem PVDC tseem yog txoj kev lag luam tshaj rau ntxiv cov teeb meem dej thiab cov pa oxygen rau cov yeeb yaj kiab PVC. PVDC blister film muaj nyob rau hauv 2 lossis 3 txheej txheej txheem xa mus ua cov duplex lossis triplex. Txij li thaum PVDC tau thov los ntawm txheej txheej txheej, txheej txheej hnyav yog qhia hauv grams tauj ib square meter (gsm). Cov txheej txheem duplex feem ntau yog PVC / PVDC zaj duab xis, los ntawm 250μPVC / 40gsmPVDC txog 250μPVC / 120gsmPVDC nrog WVTR los ntawm 0,65 txog 0,25 g / m2 / d thiab OTR los ntawm 1 txog 0,1 cc / m2 / d. Rau kev sib sib zog nqus kos cov thermoformed kab noj hniav, cov lus qhia tshwj xeeb triplex raug siv: PVC / PE / PVDC, qhov twg txheej txheej PE pab thaum ua cov kab noj hniav tob. PE (polyethylene) tsim cov ntawv mos ua nruab nrab ntawm cov npoo tsis yeem PVC thiab PVDC txheej. Cov lus qhia tshwj xeeb ntawm Triplex muaj nyob rau qhov hnyav txheej zoo li cov khoom duplex: 250μPVC / 25μPE / 40gsmPVDC txog 250μPVC / 25μPE / 120gsmPVDC. Txhawm rau kom tau txais cov khoom siab lub zog, PVDC ib txwm thov siv cov txheej txheem emulsion txheej txheem siv cov PVDC cob ua rau dej tawg. Cov neeg tsim yeeb yaj kiab siv cov xim txheej hauv ntau kauj ruam, ziab tawm ntawm cov dej ntawm txhua lub chaw pleev xim.
PVDC qib muaj nyob rau hauv 2 hom polymer: (I) cov qib keeb kwm muab cov khoom nruab nrab rau qhov muaj cov khoom siv tsis zoo thiab (II) ib txheej super barrier txheej qib muab qhov siab tshaj plaws thaiv. Tus txheej txheem super barrier txheej muaj ntau dua ob zaug qhov teeb meem ntawm noo noo thiab oxygen rau ib txheej hnyav qhov hnyav piv rau cov qib keeb kwm. Cov txheej txheem feem ntau uas siv cov txheej txheem super PVDC yog triplex teeb tsa 250μ PVC / 25μ PE / 120gsm PVDC txog 250μ PVC / 25μ PE / 180gsm PVDC, nrog WVTR ntawm 0,11 nqis mus rau 0,06 g / m2 / hnub thiab muaj los ntawm ntau yam tsum.